CBE-Life Science Education has an article on the relevance of textbooks in this mordern era.The author shares his experience of teaching with and without a textbook.
Are textbooks just for reference and not learning tools?
Take a look.
The author has given some webpages containing course materials
1. Biofundamentals (http://www.colorado.edu/MCDB/MCDB1111)
2.Flash based virtual laboratories (http://bioliteracy.net/)